林开利-中国科学院大学-UCAS


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林开利-中国科学院大学-UCAS
[中文]
[English]
招生信息
教育背景
工作经历
专利与奖励
出版信息
科研活动
指导学生
基本信息
林开利 男 硕导 上海硅酸盐研究所 电子邮件:lklsic@mail.sic.ac.cn 通信地址:上海市定西路1295号 邮政编码:200050
招生信息
招生专业
080502-材料学070304-物理化学(含:化学物理)085204-材料工程
招生方向
生物材料、纳米生物材料、生物陶瓷、复合生物材料 材料微纳结构调控与性能研究 组织工程、骨修复材料
教育背景
2005-09--2008-07 华东师范大学 博士 1998-09--2001-07 华东师范大学 硕士 1994-09--1998-09 漳州师范学院 学士
工作经历
工作简历
2013-09--今 中国科学院上海硅酸盐研究所 研究员 2009-09--2013-09 中国科学院上海硅酸盐研究所 副研究员 2004-01--2009-08 中国科学院上海硅酸盐研究所 助理研究员 2001-07--2003-12 中国科学院上海硅酸盐研究所 研究实习员
社会兼职
2012-01--今 上海市硅酸盐学会生物与环保材料专业委员会,委员 2011-01--今 上海市生物医学工程学会生物材料专业委员会,委员
专利与奖励
奖励信息
(1) 中国科学院青年创新促进会会员,院级级,2012 (2) 中国科学院卢嘉锡青年人才奖,院级级,2011 (3) 年度个人先进荣誉称号,研究所(学校)级,2011 (4) 第九届中韩生物材料和纳米生物材料会议最佳报告奖,其他级,2011 (5) 优秀毕业研究生称号,研究所(学校)级,2001
专利成果
(1) 聚酯增强可降解多孔硅酸钙复合支架材料、制备及用途,发明,2009,第2作者,专利号:200910095708.9 (2) 可降解多孔硅酸钙陶瓷生物活性材料的制备方法,发明,2005,第1作者,专利号:02137248.9,作为核心专利基础之一,开发的复合材料正进入临床试验. (3) 多孔硅酸钙/β-磷酸三钙复相生物陶瓷材料的制备方法,发明,2005,第1作者,专利号:03115941.9 (4) 原位化学沉淀法制备硅酸钙/β-磷酸三钙复合粉体的方法,发明,2007,第2作者,专利号:200510111365.2 (5) 硅酸钙前驱体水热制备羟基磷灰石粉体的方法,发明,2011,第2作者,专利号:201110041186.1 (6) 硬模板水热控制羟基磷灰石粉体形貌的方法,发明,2011,第2作者,专利号:201110170339.2 (7) 两步化学沉淀法制备硅酸钙/β-磷酸三钙纳米复合粉体的方法,发明,2008,第2作者,专利号:200510111366.7 (8) 透明β-磷酸三钙生物陶瓷材料的制备与应用,发明,2009,第2作者,专利号:200510030788.1 (9) 医用增强型多孔生物陶瓷制备方法及其应用,发明,2009,第4作者,专利号:200610026058.9,转化的医疗器械产品已经进入临床应用领域. (10) 硅酸钙羟基磷灰石复合生物陶瓷材料及其制备方法和用途,发明,2009,第2作者,专利号:200910198812.0 (11) 硅酸钙纳米线羟基磷灰石纳米颗粒复合粉体的制备方法,发明,2009,第2作者,专利号:200910198811.6 (12) 硬模板水热控制羟基磷灰石粉体形貌的方法,发明,2011,第2作者,专利号:201110170339.2
出版信息
发表论文
(1) A comparative study of proliferation and osteogenic differentiation of rat adipose-derived stem cells in β-tricalcium phosphate (β-TCP), forsterite (Mg2SiO4) and clinoenstatite (MgSiO3),Chinese Science Bulletin,2013,第5作者 (2) Hollow magnetic hydroxyapatite microspheres with hierarchically mesoporous microstructure for drug delivery,CrystEngComm,2013,通讯作者 (3) Mesoporous strontium substituted hydroxyapatite microspheres: surfactant-free hydrothermal synthesis, enhanced biological response and sustained drug release,Chemical Engineering Journal,2013,第1作者 (4) Osteogenesis and angiogenesis induced by porous β- CaSiO3/PDLGA composite scaffold via activation of AMPK / ERK1/2 and PI3K/ Akt pathways,Biomaterials,2013,第1作者 (5) Facile fabrication of nanorod-assembled fluorine-substituted hydroxyapatite (FHA) microspheres,Chemistry - An Asian Journal,2013,第3作者 (6) Effect of calcium silicate on in vitro physiochemical properties and in vivo osteogenisis, degradability and bioactivity of porous β-tricalcium phosphate bioceramics,Biomedical Materials,2013,第3作者 (7) Efficient adsorption and photocatalytic degradation of Congo red onto hydrothermally synthesized NiS nanoparticles,Journal of Nanopartical Research,2013,第4作者 (8) Preparation and characterization of PLLA/CaSiO3/Apatite composite films,International Journal of Applied Ceramic Technology,2012,第3作者 (9) Effect of heat treatment on the properties of SiO2-CaO-MgO- P2O5 bioactive glasses,Journal of Material Science: Material in Medicine,2012,第3作者 (10) Fabrication of dense hydroxyapatite nano-bioceramics with enhanced mechanical properties via two-step sintering process,International Journal of Applied Ceramics Technology,2012,第1作者 (11) Synthesis of strontium substituted hydroxyapatite whiskers used as bioactive and mechanical reinforcement material,Materials letters,2012,通讯作者 (12) Biological responses of human bone marrow mesenchymal stem cells to Sr-M-Si (M = Zn, Mg) silicate bioceramics,Journal of Biomedical Materials Research. Part A,2012,第3作者 (13) The effect of poly(lactic-co-glycolic acid) (PLGA) coating on the mechanical, biodegradable, bioactive properties and drug release of porous calcium silicate scaffolds,Bio-Medical Materials and Engineering,2012,第3作者 (14) Dental enamel-like hydroxyapatite transformed directly from monetite,Journal of Materials Chemistry,2012,通讯作者 (15) Mechanical and thermal properties of denture pmma reinforced with silicon aluminum borate whiskers,Dental Materials Journal,2012,第4作者 (16) Preparation and characterization of Sr-hardystonite (Sr2ZnSi2O7) for bone repair applications,Materials Sciences and Engineering C,2012,第2作者 (17) In vivo degradation and osteogenic effect of β-CaSiO3/β-Ca3(PO4)2 composite porous bioceramic scaffolds,Acta Biomaterialia,2012,第3作者 (18) Ultrafast synthesis and characterization of carbonated hydroxyapatite nanopowders via sonochemistry-assisted microwave process,Ultrasonics Sonochemistry,2012,第2作者 (19) Sulfanilic acid-modified P25 TiO2 nanoparticles with improved photocatalytic degradation on Congo red under visible light,Dyes and Pigments,2012,第2作者 (20) Growth of Highly Oriented Hydroxyapatite Arrays Tuned by Quercetin,Chemistry-A European Journal,2012,第2作者 (21) Preparation and characterization of clinoenstatite bioceramics,Journal of the American Ceramic Society,2011,第4作者 (22) Facile synthesis of hydroxyapatite nanoparticles, nanowires and hollow nano-structured microspheres using similar structured hard-precursors,Nanoscale,2011,通讯作者 (23) pH effects on solid/liquid interface – the critical factor to stimulate osteoporotic bone regeneration,Langmuir,2011,第3作者 (24) Modulation of hydroxyapatite crystal formed from alpha-tricalcium phosphate by surfactant-free hydrothermal exchange,CrystEngComm,2011,第2作者 (25) Effects of strontium in modified biomaterials,Acta Biomaterialia,2011,第4作者 (26) Hierarchically Structured Nanocrystalline Hydroxyapatite Assembled Hollow Fibers as a Promising Protein Delivery System,Chemical Communications,2011,第3作者 (27) Synthesis of the element-substituted hydroxyapatite with controllable morphologies and chemical compositions using calcium silicate as precursor,CrystEngComm,2011,第1作者 (28) Improvement of mechanical properties of macroporous β-tricalcium phosphate bioceramic scaffolds with uniform and interconnected porous structures,Ceramics Internationals,2011,第1作者 (29) Evaluation of host inflammatory responses of β-tricalcium phosphate bioceramics caused by calcium pyrophosphate impurity using a subcutaneous model,Journal of Biomedical Materials Research, Part B-Applied Biomaterials,2011,第1作者 (30) Biomimetic hydroxyapatite porous microspheres with co-substituted essential trace elements: surfactant-free hydrothermal synthesis, enhanced degradation and drug release,Journal of Materials Chemistry,2011,第1作者 (31) Jiang Chang, The influences of poly(lactic-co-glycolic acid) (PLGA) coating on the biodegradability, bioactivity and biocompatibility of calcium silicate bioceramics,Journal of Materials Science,2011,第2作者 (32) Polymer nanocomposites with controllable distribution and arrangement of inorganic nanocomponents,Nanoscale,2011,第2作者 (33) Fabrication and characterization of hydroxyapatite/wollastonite composite bioceramics with controllable properties for hard tissue repair,Journal of the American Ceramic Society,2011,第1作者 (34) Synthesis, in vitro hydroxyapatite forming ability and cytocompatibility of strontium silicate powders,Journal of Biomedical Materials Research: Part B-Applied Biomaterials,2010,第3作者 (35) Synthesis and Characterization of nano-composite powders composed of hydroxyapatite nanoparticles and wollastonite nanowires,International Journal of Applied Ceramic Technology,2010,第1作者 (36) Study the adsorption of phenol from aqueous solution on hydroxyapatite nanopowders,Journal of Hazardous Materials,2009,第1作者 (37) A facile one-step surfactant-free and low-temperature hydrothermal method to prepare uniform 3D structured carbonated apatite flowers,Crystal Growth Design,2009,第1作者 (38) The effect of powder properties on sintering, microstructure, mechanical strength and degradability of β-tricalcium phosphate/calcium silicate composite bioceramics,Biomedical Materials,2009,第1作者 (39) Fabrication and characterization of 45S5 bioglass reinforced macroporous calcium silicate bioceramics,Journal of the European Ceramic Society,2009,第1作者 (40) β-CaSiO3/β-Ca3(PO4)2 composite materials for hard tissue repair: in vitro studies,Journal of Biomedical Materials Research,2008,第2作者 (41) Spark plasma sintering of macroporous calcium phosphate scaffolds from nanocrystalline powders,Journal of the European Ceramic Society,2008,第2作者 (42) Reconstruction of calvarial defect of rabbits using porous calcium silicate bioactive ceramics,Biomaterials,2008,第1作者 (43) Preparation, mechanical properties and in vitro degradability of wollastonite/tricalcium phosphate macroporous scaffolds from nanocomposite powders,Journal of Materials Sciences: Materials in Medicine,2008,第3作者 (44) In vitro hydroxyapatite forming ability and dissolution of tobermorite nanofibers,Acta Biomaterialia,2007,第1作者 (45) Bioinspired structure of bioceramics for bone regeneration in load bearing sites,Acta Biomaterials,2007,第4作者 (46) A simple method to synthesize single-crystalline β-wollastonite nanowires,Journal of crystal growth,2007,第1作者 (47) Hydrothermal microemulsion synthesis of stoichiometric single crystal hydroxyapatite nanorods with mono-dispersion and narrow size distribution,Materials letters,2007,第1作者 (48) Properties of β-Ca3(PO4)2 bioceramics prepared using nano-size powders,Ceramics International,2007,第1作者 (49) 采用超细粉体和放电等离子烧结技术制备透明β-磷酸三钙生物陶瓷的研究,无机材料学报,2006,第1作者 (50) Synthesis of wollastonite nanowires via hydrothermal microemulsion methods,Materials Letters,2006,第1作者 (51) Study of the mechanical property and in vitro biocompatibility of CaSiO3 ceramics,Ceramics International,2005,第1作者 (52) 多孔硅酸钙生物陶瓷的制备及体外活性和降解性研究,无机材料学报,2005,第1作者 (53) Preparation of macroporous calcium silicate ceramics,Materials Letters,2004,第1作者
发表著作
(1) 骨修复和药物载体用先进无机活性材料,Preparation and mechanism of novel bioceramics with controllable morphology and crystal growth, in Advanced Bioactive Inorganic Materials for Bone Regeneration and Drug Delivery,CRC press,2013-03,第1作者 (2) 羟基磷灰石:制备、性能和应用,Morphology Control of Hydroxyapatite Crystal and its Aggregates, in Hydroxyapatite: Synthesis, Properties and Applications,Nova Science Publishers,2012-12,第2作者
科研活动
科研项目
(1) 中国科学院青年创新促进会会员费,主持,院级级,2012-06--2015-12 (2) 羟基磷灰石表面微纳米结构及组成的可控制备与生物学效应研究,主持,国家级,2012-01--2015-12 (3) 磷灰石及其复合植骨材料的可控自组装制备及性能研究,主持,研究所(学校)级,2012-01--2014-12 (4) 用于修复骨质疏松骨缺损的新型掺锶硅酸钙材料的研究,参与,国家级,2011-01--2013-12 (5) 多孔硅酸钙生物陶瓷的成骨与降解机理研究,主持,国家级,2010-01--2010-12 (6) 表面微纳米化及阵列结构羟基磷灰石生物陶瓷的制备和性能研究,主持,专项级,2010-01--2012-12
参与会议
(1) Biomimetic hydroxyapatite porous microspheres with co-substituted essential trace elements: surfactant-free hydrothermal synthesis, enhanced degradation and drug release,2012-06,Kaili Lin, Jiang Chang (2) Hydrothermal Synthesis of Hydroxyapatite with Controllable Morphologies and Composition using Calcium Silicate as Precursor,2011-12,林开利、常江 (3) 羟基磷灰石骨修复生物陶瓷的微纳米结构/组成调控及性能研究,中科院上硅所与清华大学学术交流研讨会,2011-10,林开利 (4) 硬模板水热控制羟基磷灰石粉体形貌,中国生物医学工程学会生物材料分会第十三届学术年会,2011-09,林开利, 常江 (5) Calcium silicate and strontium containing calcium silicate bioceramics: potential applications in bone and osteoporotic bone regeneration,2011 中美中医药治疗骨质疏松症学术研讨会,2011-01,Kaili Lin, Jiang Chang (6) Fabrication and Characterization of Hydroxyapatite-Wollastonite Composite Bioceramics with Controllable Properties for Hard Tissue Repair,亚洲材料联合会,2010-09,Kaili Lin, Meili Zhang, Wanyin Zhai, Jiang Chang
指导学生
现指导学生张娜 硕士研究生 085204-材料工程 王秀惠 硕士研究生 085204-材料工程
2013 中国科学院大学,网络信息中心.