黄福德-中国科学院大学-UCAS
[中文]
[English]
招生信息
教育背景
工作经历
教授课程
专利与奖励
出版信息
科研活动
指导学生
基本信息
黄福德 男 博导 中国科学院上海高等研究院电子邮件： huangfd@sari.ac.cn通信地址： 上海市海科路99号6号楼邮政编码： 201210
研究领域
​1.神经退行性疾病的细胞分子机制，治疗靶点及药物筛选。2.缺氧损伤和缺氧耐受。3.成体神经干细胞在生理和病理条件下增生与分化的调节。
招生信息
招生专业
071006-神经生物学071010-生物化学与分子生物学070321-化学生物学
招生方向
神经退性疾病的细胞分子机制研究, 治疗靶点和药物筛选成体神经干细胞在病理条件下的增殖与分化缺氧损伤和缺氧耐受
教育背景
2002-09--2005-12 美国范德堡大学 （Vanderbilt University） Ph.D1999-09--2002-08 美国犹他大学（University of Utah） 神经科学研究生1997-10--1999-08 新加坡国立大学（National University of Singapore） 硕士1994-09--1997-07 中国科学院上海脑研究所 神经生物学硕士学位1987-09--1992-07 衡阳医学院 临床医疗学士学位
学历
-- 研究生
学位
-- 博士
工作经历
2006.1-2008.1，中国科学院上海生命科学院神经科学研究所，副研究员2008.1-2013.1，中国科学院上海生命科学院神经科学研究所，研究员，神经退行性疾病小组组长。2013.1- 中国科学院上海高等研究院神经科学研究所，研究员，神经退行性疾病课题组组长。 2015.10- 中国科学院大学岗位教授
工作简历
2015-10~现在, 中国科学院大学, 岗位教授2013-01~现在, 中科院上海高等研究院, 研究员2008-01~2012-12,中科院上海生命科学院神经所, 研究员2006-01~2007-12,中科院上海生命科学院神经所, 副研究员1992-08~1994-08,湖南省汝城县人民医院, 住院医师
教授课程
神经科学中的动物模型神经科学
专利与奖励
1 Huang FD. (2014), Patent number: 201420128803.02 Huang et al. (2015), Patent number: 201210234165.63 Huang et al. (2015), Patent application number: PCT/CN2015/0780704 Huang et al. (2016), Patent application number: PCT/CN2016/080907
专利成果
（ 1 ）&nbspRbo/efr3a/efr3b基因或其蛋白在诊断和治疗阿尔兹海默病中的作用,&nbsp发明,&nbsp2012,&nbsp第 1 作者,&nbsp专利号: 201210234165.6（ 2 ）&nbsp一种自动检测昆虫移行能力的装置,&nbsp实用新型,&nbsp2014,&nbsp第 1 作者,&nbsp专利号: 201420128803.0（ 3 ）&nbspPI4KIIIa蛋白及相关膜蛋白复合体,&nbsp发明,&nbsp2015,&nbsp第 1 作者,&nbsp专利号: PCT/CN2015/078058（ 4 ）&nbsp一种筛选治疗阿尔茨海默病的药物和靶点的方法,&nbsp发明,&nbsp2015,&nbsp第 1 作者,&nbsp专利号: PCT/CN2015/078070（ 5 ）&nbsp一种筛选治疗阿尔茨海默病的药物和靶点的方法 （专利申请人是被转让企业）,&nbsp发明,&nbsp2016,&nbsp第 1 作者,&nbsp专利号: PCT/CN2016/080907（ 6 ）&nbsp抑制肝纤维化的小分子化合物及应用,&nbsp发明,&nbsp2017,&nbsp第 1 作者,&nbsp专利号: 201710245431.8（ 7 ）&nbsp抑制肝纤维化的试剂及应用 等,&nbsp发明,&nbsp2017,&nbsp第 1 作者,&nbsp专利号: 201710245671.8
出版信息
发表论文
[1] Zhang, Qichao., Zhang, Baozhu, Lim, Nastasia K.H., Zhang, Xiao, Meng, Shiquan, Nyengaard, Jens R., Huang, Fu-De, Wang, Wen-An. Hyccin/FAM126A deficiency reduces glial enrichment and axonal sheath, which are rescued by overexpression of a plasma membrane-targeting PI4KIIIalpha in Drosophila. BBRC[J]. 2022, 589: 71-77, https://www.ncbi.nlm.nih.gov/pubmed/34894559.[2] Xie, Yiyu, Huang, Jason J., Zhang, Hao, Hong, Feng, Huang, Fu-De, Wang, Wen-An. Phenylarsine oxide inhibits the accumulation of lipid droplets in macrophages. ABBS[J]. 2022, https://www.ncbi.nlm.nih.gov/pubmed/36239353.[3] Zheng, Linan, Hong, Feng, Huang, Fude, Wang, Wenan. Inhibition of PI4KIII alpha as a Novel Potential Approach for Gaucher Disease Treatment. NEUROSCIENCE BULLETIN. 2021, 37(8):&nbsp1234-1239, http://dx.doi.org/10.1007/s12264-021-00704-w.[4] Du, Qingqing, Lim, Nastasia K H, Xia, Yiling, Xu, Wangchao, Zhang, Qichao, Zhang, Liyao, Huang, Fude, Wang, Wenan. Pgant4 and Tango1 Mediate Anoxia and Reoxygenation Injury. NEUROSCIENCE BULLETIN. 2020, 36(12):&nbsp1552-1557, http://lib.cqvip.com/Qikan/Article/Detail?id=7103720246.[5] Mu, Shujing, Lim, Nastasia K H, Huang, Fude. Inhibition of phosphatidylinositol kinase-III alpha induces or facilitates lysosome exocytosis from microglia.. NEUROREPORT[J]. 2020, 31(10):&nbsp697-701, https://www.webofscience.com/wos/woscc/full-record/WOS:000545918200001.[6] He, Yang, Wei, Mengdi, Wu, Yan, Qin, Huaping, Li, Weinan, Ma, Xiaolin, Cheng, Jingjing, Ren, Jinshuai, Shen, Ye, Chen, Zhong, Sun, Binggui, Huang, FuDe, Shen, Yi, Zhou, YuDong. Amyloid beta oligomers suppress excitatory transmitter release via presynaptic depletion of phosphatidylinositol-4,5-bisphosphate. NATURE COMMUNICATIONS[J]. 2019, 10: http://dx.doi.org/10.1038/s41467-019-09114-z.[7] Sun, Minghao, Zhao, Yinghui, Han, Men, Zhang, Baozhu, Zhang, Xiao, Zhang, Qichao, Lim, Nastasia KH, Wang, WenAn, Huang, FuDe. TTC7 and Hyccin Regulate Neuronal A beta(42) Accumulation and its Associated Neural Deficits in A beta(42)-Expressing Drosophila. JOURNAL OF ALZHEIMERS DISEASE[J]. 2018, 65(3):&nbsp1001-1010, https://www.webofscience.com/wos/woscc/full-record/WOS:000444339800023.[8] Lim, Nastasia KH, Moestrup, Visse, Zhang, Xiao, Wang, WenAn, Moller, Arne, Huang, FuDe. An Improved Method for Collection of Cerebrospinal Fluid from Anesthetized Mice. JOVE-JOURNAL OF VISUALIZED EXPERIMENTS[J]. 2018, https://www.webofscience.com/wos/woscc/full-record/WOS:000443329500126.[9] Xia, Yiling, Xu, Wangchao, Meng, Shiquan, Lim, Nastasia K H, Wang, Wenan, Huang, FuDe. An Efficient and Reliable Assay for Investigating the Effects of Hypoxia/Anoxia on Drosophila. NEUROSCIENCE BULLETIN[J]. 2018, 34(2):&nbsp397-402, http://lib.cqvip.com/Qikan/Article/Detail?id=674956891.[10] Wenze Cao, Li Song, Jingjing Cheng, Na Yi, Luyi Cai, Fude Huang, Margaret Ho. An Automated Rapid Iterative Negative Geotaxis Assay for Analyzing Adult Climbing Behavior in a Drosophila Model of Neurodegeneration. Journal of Visualized Experiments : JoVE. 2017, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5752225/.[11] 黄福德. SH2B1 is involved in the accumulation of Aβ42 in Alzheimer’s disease model. Journal of Alzheimer's Disease. 2017, [12] 黄福德. Down regulation of RBO-PI4KIIIα facilitates Aβ42 secretion and ameliorates neural deficits in Drosophila. J. Neurosci.. 2017, [13] Hu, Haixia, Ye, Bin, Zhang, Le, Wang, Quan, Liu, Zhiwei, Ji, Suying, Liu, Qiuju, Lv, Jingrong, Ma, Yan, Xu, Ying, Wu, Hao, Huang, Fude, Xiang, Mingliang. Efr3a Insufficiency Attenuates the Degeneration of Spiral Ganglion Neurons after Hair Cell Loss. FRONTIERS IN MOLECULAR NEUROSCIENCE[J]. 2017, 10: https://www.webofscience.com/wos/woscc/full-record/WOS:000397570500001.[14] Qian, Qi, Liu, Qiuji, Zhou, Dongming, Pan, Hongyu, Liu, Zhiwei, He, Fangping, Ji, Suying, Wang, Dongpi, Bao, Wangxiao, Liu, Xinyi, Liu, Zhaoling, Zhang, Heng, Zhang, Xiaoqin, Zhang, Ling, Wang, Mingkai, Xu, Ying, Huang, Fude, Luo, Benyan, Sun, Binggui. Brain-specific ablation of Efr3a promotes adult hippocampal neurogenesis via the brain-derived neurotrophic factor pathway. FASEB JOURNAL[J]. 2017, 31(5):&nbsp2104-2113, https://www.webofscience.com/wos/woscc/full-record/WOS:000399195500029.[15] 仝艳艳, 李光明, 邓怡林, 石翠翠, 黄福德, 范建高. 氧化苯砷体外对大鼠原代肝星状细胞活化的阻抑作用研究. 实用肝脏病杂志[J]. 2016, 19(4):&nbsp413-417, http://lib.cqvip.com/Qikan/Article/Detail?id=669540701.[16] Shen, YiJun, Wang, WenAn, Huang, FuDe, Chen, Jie, Liu, HaiYan, Xia, YiLing, Han, Meng, Zhang, Le. The use of MMSE and MoCA in patients with acute ischemic stroke in clinical. INTERNATIONAL JOURNAL OF NEUROSCIENCE[J]. 2016, 126(5):&nbsp442-447, https://www.webofscience.com/wos/woscc/full-record/WOS:000376392400010.[17] 韩萌, 马萍丽, 叶春艳, 张保柱, 章海燕, 孙晓江, 黄福德. 阿尔茨海默病果蝇模型中Aβ毒性的长度依赖性. 中国老年学杂志[J]. 2015, 1315-, http://lib.cqvip.com/Qikan/Article/Detail?id=90768890504849534853485557.[18] Liu Haiyan, Han Meng, Li Qingyi, Zhang Xiao, Wang Wenan, Huang Fude. Automated rapid iterative negative geotaxis assay and its use in a genetic screen for modifi ers of Aβ_(42)-induced locomotor decline in Drosophila. Neuroscience Bulletin[J]. 2015, 31(5):&nbsp541-549, [19] 黄福德. Automated rapid iterative negative geotaxis assay and its use in a genetic screening for modifiers of Aβ42-induced locomotor decline in Drosophila. Neuroscience Bulletin. 2015, [20] Han, M, Huang, J K, Liu, H Y, Wang, W A, Sun, X J, Huang, F D. Neither insufficiency nor overexpression of sac1 affects the accumulation of A beta(42) in Drosophila expressing A beta(42). EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES[J]. 2015, 19(9):&nbsp1700-1705, https://www.webofscience.com/wos/woscc/full-record/WOS:000355744400024.[21] 黄福德. The toxicity of beta amyloid peptide depends on its length in transgenic Drosophila model of Alzheimer’s disease. China Journal of Gerontology. 2015, [22] Lin Jingya, Wang Wenan, Zhang Xiao, Liu Haiyan, Zhao Xiaoliang, Huang Fude. Intraneuronal accumulation of Aβ_(42) induces age-dependent slowing of neuronal transmission in Drosophila. Neuroscience Bulletin[J]. 2014, 30(2):&nbsp185-190, [23] 黄福德. β淀粉样肽在阿尔兹海默病中作用的逐步认识. 生命科学[J]. 2014, 26(1):&nbsp9-14, [24] Lin, JingYa, Wang, WenAn, Zhang, Xiao, Liu, HaiYan, Zhao, XiaoLiang, Huang, FuDe. Intraneuronal accumulation of A beta(42) induces age-dependent slowing of neuronal transmission in Drosophila. NEUROSCIENCE BULLETIN[J]. 2014, 30(2):&nbsp185-190, http://www.irgrid.ac.cn/handle/1471x/850744.[25] Huang, JianKang, Ma, PingLi, Ji, SuYing, Zhao, XiaoLiang, Tan, JiangXiu, Sun, XiaoJiang, Huang, FuDe. Age-dependent alterations in the presynaptic active zone in a Drosophila model of Alzheimer's Disease. NEUROBIOLOGY OF DISEASE[J]. 2013, 51(1):&nbsp161-167, http://dx.doi.org/10.1016/j.nbd.2012.11.006.[26] Bao, GuanShui, Wang, WenAn, Wang, TianZhe, Huang, JianKang, He, Hua, Liu, Zhenguo, Huang, FuDe. Overexpression of Human MRP1 in Neurons causes resistance to Antiepileptic Drugs in Drosophila Seizure Mutants. JOURNAL OF NEUROGENETICS[J]. 2011, 25(4):&nbsp201-206, http://www.irgrid.ac.cn/handle/1471x/502283.[27] XiaoLiang Zhao, WenAn Wang, JiangXiu Tan, JianKang Huang, Xiao Zhang, BaoZhu Zhang, YuHang Wang, HanYu YangCheng, HongLian Zhu, XiaoJiang Sun, FuDe Huang. Expression of β-Amyloid Induced Age-Dependent Presynaptic and Axonal Changes in Drosophila. The Journal of Neuroscience. 2010, 30(4):&nbsp1512-1522, [28] Yu, Y, Xu, C, Pan, X, Ren, H, Wang, W, Meng, X, Huang, F, Chen, N. Identification and functional analysis of novel mutations of the CLCNKB gene in Chinese patients with classic Bartter syndrome. CLINICAL GENETICS[J]. 2010, 77(2):&nbsp155-162, http://www.irgrid.ac.cn/handle/1471x/502347.[29] 黄福德. Rolling Blackout is required for synaptic vesicle exocytosis in Drosophila. Journal of neuroscience. 2006, [30] Tai, SK, Huang, FD, Moochhala, S, Khanna, S. Hippocampal theta state in relation to formalin nociception. PAIN[J]. 2006, 121(1-2):&nbsp29-42, http://dx.doi.org/10.1016/j.pain.2005.11.016.[31] Huang, FD, Matthies, HJG, Speese, SD, Smith, MA, Broadie, K. Rolling blackout, a newly identified PIP2-DAG pathway lipase required for Drosophila phototransduction. NATURE NEUROSCIENCE[J]. 2004, 7(10):&nbsp1070-1078, https://www.webofscience.com/wos/woscc/full-record/WOS:000224156900016.[32] Huang, FD, Chen, J, Lin, M, Keating, MT, Sanguinetti, MC. Long-QT syndrome-associated missense mutations in the pore helix of the HERG potassium channel. CIRCULATION[J]. 2001, 104(9):&nbsp1071-1075, https://www.webofscience.com/wos/woscc/full-record/WOS:000170774400028.[33] 黄福德. Neuronal activity of monkey dorso-lateral premotor cortex during tasks of figure recognition guided motor sequence vs memorized spatial motor sequence. ACTA PHYSIOLOGICA SINICA. 1998,
科研活动
科研项目
（ 1 ）&nbsp条件性敲除Efr3a基因对 APP/Psn 转基因小鼠神经退行性变的影响及机制研究, 主持, 国家级, 2014-01--2017-12（ 2 ）&nbspHyccin缺失导致神经髓鞘形成不良的动物模型构建及机制研究, 主持, 国家级, 2016-01--2019-12（ 3 ）&nbsp老年痴呆症相关分子标记和潜在治疗靶点的筛选与鉴定, 主持, 国家级, 2013-01--2017-12（ 4 ）&nbsp阿尔茨海默病新靶点和化合物筛选, 主持, 院级, 2015-06--2020-08（ 5 ）&nbspPI4KIIIa及其抑制剂在焦虑抑郁中的作用与机制 （挂靠中科院药物所，可续）, 主持, 国家级, 2017-01--2018-12
指导学生
已指导学生马平丽 02 19179 张潇 01 19179 张建夫 02 63228 蒋理想 02 63228 现指导学生孙名皓 02 63228 张起超 02 19179 张丽瑶 02 19179 沐舒静 02 63228
2013 中国科学院大学，网络信息中心.