惠静毅-中国科学院大学-UCAS
[中文]
[English]
教育背景
工作经历
专利与奖励
出版信息
科研活动
指导学生
基本信息
惠静毅 女 博导 中国科学院上海生命科学研究院电子邮件： jyhui@sibs.ac.cn通信地址： 上海市徐汇区岳阳路320号新生化大楼1311室邮政编码：
招生信息
招生专业
071010-生物化学与分子生物学
招生方向
哺乳动物细胞mRNA剪接的调控与功能
教育背景
1999-09--2003-05 德国尤斯图斯-李比希-吉森大学 博士1998-08--1999-08 德国柏林自由大学 硕士1989-09--1993-07 上海复旦大学生命科学院 学士
工作经历
工作简历
2008-06~现在, 中科院上海生命科学研究院生化细胞所, 研究组长2006-11~2008-05,德国弗里德利希-亚力山大-埃尔兰根纽伦堡大学, 博士后2003-06~2006-10,德国尤斯图斯-李比希-吉森大学, 博士后
专利与奖励
专利成果
（ 1 ）&nbsp含前表面抗原1和2免疫决定簇的乙肝表面抗原,&nbsp发明,&nbsp2001,&nbsp第 2 作者,&nbsp专利号: ZL 96 1 16417.4（ 2 ）&nbsp一种抗QKI-5单克隆抗体及其制备与应用,&nbsp发明,&nbsp2014,&nbsp第 1 作者,&nbsp专利号: 20140842403.0
出版信息
发表论文
[1] Jin-Zhu Wang, Hong Zhu, Pu You, Hui Liu, Wei-kang wang, Xiaojuan Fan, yun yang, keren xu, Yingfeng Zhu, Qunyi Li, Ping Wu, Chao Peng, Catherine C.L. Wong, Kaicheng Li, Yufeng Shi, Nu Zhang, Xiuxing Wang, Rong Zeng, Ying Huang, Liusong Yang, Zefeng Wang, hui jingyi. Upregulated YB-1 protein promotes glioblastoma growth through a YB-1/CCT4/mLST8/mTOR pathway. J Clin Invest[J]. 2022, [2] Yun Yang, Qianyun Lu, Zefeng Wang, ZiLong Qiu, Jingrong Zhao, Tianling Cheng, YanQing Zhong, Xingyu Pan, Xu Zhang, Yang Jiao, Jijun Chen, Jing Pan, Xuye Hu, YingJin Lu, ChangLin Li, Bin Wang, Jianmin Zhu, Zhenxing Yang, HuaSheng Xiao, Zhiying Zhou, Meizhu Bai, Jinsong Li, Lei Diao, Yuxuan Wu, Lan Bao, Jingyi Hui. 5 ' UTR SNP of FGF13 causes translational defect and intellectual disability. ELIFE[J]. 2021, 10: http://dx.doi.org/10.7554/eLife.63021.[3] Park, Eddie, Jiang, Yan, Hao, Lili, Hui, Jingyi, Xing, Yi. Genetic variation and microRNA targeting of A-to-I RNA editing fine tune human tissue transcriptomes. GENOME BIOLOGY[J]. 2021, 22(1):&nbsphttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7942016/.[4] Yang, Wenjun, Yang, Lele, Wang, Jianhua, Zhang, Yuanyuan, Li, Sheng, Yin, Qi, Suo, Jinlong, Ma, Ruimiao, Ye, Yuzhen, Cheng, Hong, Li, Jinsong, Hui, Jingyi, Hu, Ping. Msi2-mediated MiR7a-1 processing repression promotes myogenesis. JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE. 2021, 13(1):&nbsp728-742, http://dx.doi.org/10.1002/jcsm.12882.[5] Jiang, Yan, Fu, Xing, Zhang, Yuhan, Wang, ShenFei, Zhu, Hong, Wang, WeiKang, Zhang, Lin, Wu, Ping, Wong, Catherine C L, Li, Jinsong, Ma, Jinbiao, Guan, JiSong, Huang, Ying, Hui, Jingyi. Rett syndrome linked to defects in forming the MeCP2/Rbfox/LASR complex in mouse models. NATURE COMMUNICATIONS[J]. 2021, 12(1):&nbsphttp://dx.doi.org/10.1038/s41467-021-26084-3.[6] JinZhu Wang, Xing Fu, Zhaoyuan Fang, Hui Liu, FengYang Zong, Hong Zhu, YanFei Yu, XiaoYing Zhang, ShenFei Wang, Ying Huang, jingyi Hui. QKI-5 regulates the alternative splicing of cytoskeletal gene ADD3 in lung cancer. JOURNAL OF MOLECULAR CELL BIOLOGY[J]. 2021, 13(5):&nbsp347-360, [7] Wang, Xin, Li, ZhiTong, Yan, Yue, Lin, Penghui, Tang, Wei, Hasler, Daniele, Meduri, Rajyalakshmi, Li, Ye, Hua, MinMin, Qi, HuiTao, Lin, DiHang, Shi, HuiJuan, Hui, Jingyi, Li, Jinsong, Li, Dangsheng, Yang, JianHua, Lin, Jinzhong, Meister, Gunter, Fischer, Utz, Liu, MoFang. LARP7-Mediated U6 snRNA Modification Ensures Splicing Fidelity and Spermatogenesis in Mice. MOLECULAR CELL[J]. 2020, 77(5):&nbsp999-+, http://dx.doi.org/10.1016/j.molcel.2020.01.002.[8] MuellerMcNicoll, Michaela, Rossbach, Oliver, Hui, Jingyi, Medenbach, Jan. Auto-regulatory feedback by RNA-binding proteins. JOURNAL OF MOLECULAR CELL BIOLOGYnull. 2019, 11(10):&nbsp930-939, http://lib.cqvip.com/Qikan/Article/Detail?id=7100529595.[9] XiaoJuan Yang, Hong Zhu, ShiRong Mu, WenJuan Wei, Xun Yuan, Meng Wang, Yanchao Liu, Jingyi Hui, Ying Huang. Crystal structure of a Y-box binding protein 1 (YB-1)–RNA complex reveals key features and residues interacting with RNA. The Journal of Biological Chemistry[J]. 2019, 294(28):&nbsp10998-11010, http://dx.doi.org/10.1074/jbc.RA119.007545.[10] Wu, DaRen, Gu, KaiLi, Yu, JianCheng, Fu, Xing, Wang, XiWen, Guo, WenTing, Liao, LeQi, Zhu, Hong, Zhang, XiaoShan, Hui, Jingyi, Wang, Yangming. Opposing roles of miR-294 and MBNL1/2 in shaping the gene regulatory network of embryonic stem cells. EMBO REPORTS[J]. 2018, 19(6):&nbsphttp://202.127.25.143/handle/331003/3447.[11] Wang, Feng, Fu, Xing, Chen, Peng, Wu, Ping, Fan, Xiaojuan, Li, Na, Zhu, Hong, Jia, TingTing, Ji, Hongbin, Wang, Zefeng, Wong, Catherine C L, Hu, Ronggui, Hui, Jingyi. SPSB1-mediated HnRNP A1 ubiquitylation regulates alternative splicing and cell migration in EGF signaling. CELL RESEARCH[J]. 2017, 27(4):&nbsp540-558, https://www.webofscience.com/wos/woscc/full-record/WOS:000398770500009.[12] Wang, Fang, Song, Wei, Zhao, Hongmei, Ma, Yanni, Li, Yuxia, Zhai, Di, Pi, Jingnan, Si, Yanmin, Xu, Jiayue, Dong, Lei, Su, Rui, Zhang, Mengmeng, Zhu, Yong, Ren, Xiaoxia, Miao, Fei, Liu, Wenjie, Li, Feng, Zhang, Junwu, He, Aibin, Shan, Ge, Hui, Jingyi, Wang, Linfang, Yu, Jia. The RNA-binding protein QKI5 regulates primary miR-124-1 processing via a distal RNA motif during erythropoiesis. CELL RESEARCH[J]. 2017, 27(3):&nbsp416-439, https://www.webofscience.com/wos/woscc/full-record/WOS:000396265500011.[13] Yuan, Huairui, Li, Ni, Fu, Da, Ren, Jiale, Hui, Jingyi, Peng, Junjie, Liu, Yongfeng, Qiu, Tong, Jiang, Min, Pan, Qiang, Han, Ying, Wang, Xiaoming, Li, Qintong, Qin, Jun. Histone methyltransferase SETD2 modulates alternative splicing to inhibit intestinal tumorigenesis. JOURNAL OF CLINICAL INVESTIGATION[J]. 2017, 127(9):&nbsp3381-3397, [14] Li, Feng, Yi, Ping, Pi, Jingnan, Li, Lanfang, Hui, Jingyi, Wang, Fang, Liang, Aihua, Yu, Jia. QKI5-mediated alternative splicing of the histone variant macroH2A1 regulates gastric carcinogenesis. ONCOTARGET[J]. 2016, 7(22):&nbsp32821-32834, https://www.webofscience.com/wos/woscc/full-record/WOS:000377748500092.[15] Wu, ShuaiLai, Fu, Xing, Huang, Jinyan, Jia, TingTing, Zong, FengYang, Mu, ShiRong, Zhu, Hong, Yan, Yong, Qiu, Shuwei, Wu, Qun, Yan, Wei, Peng, Ying, Chen, Juxiang, Hui, Jingyi. Genome-wide analysis of YB-1-RNA interactions reveals a novel role of YB-1 in miRNA processing in glioblastoma multiforme. NUCLEIC ACIDS RESEARCH[J]. 2015, 43(17):&nbsp8516-8528, https://www.webofscience.com/wos/woscc/full-record/WOS:000366404600037.[16] Zong, FengYang, Fu, Xing, Wei, WenJuan, Luo, YaGe, Heiner, Monika, Cao, LiJuan, Fang, Zhaoyuan, Fang, Rong, Lu, Daru, Ji, Hongbin, Hui, Jingyi. The RNA-Binding Protein QKI Suppresses Cancer-Associated Aberrant Splicing. PLOS GENETICS[J]. 2014, 10(4):&nbsphttps://doaj.org/article/1e2e767f72fd49bea239a2d1c1499e0e.[17] Wei, WenJuan, Mu, ShiRong, Heiner, Monika, Fu, Xing, Cao, LiJuan, Gong, XiuFeng, Bindereif, Albrecht, Hui, Jingyi. YB-1 binds to CAUC motifs and stimulates exon inclusion by enhancing the recruitment of U2AF to weak polypyrimidine tracts. NUCLEIC ACIDS RESEARCH[J]. 2012, 40(17):&nbsp8622-8636, https://www.webofscience.com/wos/woscc/full-record/WOS:000309464300045.[18] Heiner, Monika, Hui, Jingyi, Schreiner, Silke, Hung, LeeHsueh, Bindereif, Albrecht. HnRNP L-mediated regulation of mammalian alternative splicing by interference with splice site recognition. RNA BIOLOGY[J]. 2010, 7(1):&nbsp56-64, https://www.webofscience.com/wos/woscc/full-record/WOS:000276197800008.[19] Kishore, Shivendra, Khanna, Amit, Zhang, Zhaiyi, Hui, Jingyi, Balwierz, Piotr J, Stefan, Mihaela, Beach, Carol, Nicholls, Robert D, Zavolan, Mihaela, Stamm, Stefan. The snoRNA MBII-52 (SNORD 115) is processed into smaller RNAs and regulates alternative splicing. HUMAN MOLECULAR GENETICS[J]. 2010, 19(7):&nbsp1153-1164, http://dx.doi.org/10.1093/hmg/ddp585.[20] Rossbach, Oliver, Hung, LeeHsueh, Schreiner, Silke, Grishina, Inna, Heiner, Monika, Hui, Jingyi, Bindereif, Albrecht. Auto- and Cross-Regulation of the hnRNP L Proteins by Alternative Splicing. MOLECULAR AND CELLULAR BIOLOGY[J]. 2009, 29(6):&nbsp1442-1451, https://www.webofscience.com/wos/woscc/full-record/WOS:000263720000006.[21] Hung, LeeHsueh, Heiner, Monika, Hui, Jingyi, Schreiner, Silke, Benes, Vladimir, Bindereif, Albrecht. Diverse roles of hnRNP L in mammalian mRNA processing: A combined microarray and RNAi analysis. RNA[J]. 2008, 14(2):&nbsp284-296, https://www.webofscience.com/wos/woscc/full-record/WOS:000252929400011.[22] Hui, JY, Stangl, K, Lane, WS, Bindereif, A. HnRNP L stimulates splicing of the eNOS gene by binding to variable-length CA repeats. NATURE STRUCTURAL BIOLOGY[J]. 2003, 10(1):&nbsp33-37, https://www.webofscience.com/wos/woscc/full-record/WOS:000180216100011.[23] Hui Jingyi. Novel function role of CA repeats and hnRNP L in RNA stability. RNA. 2003, [24] Hui Jingyi, Hung Lee-Hsueh, Heiner Monika, Schreiner Silke, Neumüller Norma, Reither Gregor, Haas Stefan A, Bindereif Albrecht. Intronic CA-repeat and CA-rich elements: a new class of regulators of mammalian alternative splicing. The EMBO Journal. 24(11):&nbsp1988-1998, https://www.webofscience.com/wos/woscc/full-record/WOS:000229588100009.
科研活动
科研项目
（ 1 ）&nbsp国家重点基础研究发展计划项目, 参与, 国家级, 2011-01--2015-08（ 2 ）&nbsp国家自然科学基金委员会面上项目, 主持, 国家级, 2010-01--2012-12（ 3 ）&nbsp国家重点基础研究发展计划项目, 参与, 国家级, 2011-01--2015-12（ 4 ）&nbsphnRNP A1蛋白泛素化在EGF信号通路中的功能与机制研究, 主持, 国家级, 2016-01--2019-12（ 5 ）&nbspQKI蛋白调控可变剪接的机制与功能研究, 主持, 国家级, 2014-01--2017-12
指导学生
已指导学生罗亚鸽 02 19183 魏文娟 01 19183 牟世荣 01 19183 贾婷婷 02 19183 宗峰阳 01 19183 吴帅来 01 19183 现指导学生王丰 01 19183 蒋琰 01 19183 俞建成 01 19183 王金柱 02 19183 刘慧 02 19183 俞燕飞 01 19183
2013 中国科学院大学，网络信息中心.